Perinatal outcome of assisted reproductive technology: Is stillbirth of significant importance?

The first in vitro fertilization (IVF) baby was born >40 years ago, and since then, >7 million babies have been using assisted reproductive technology (ART). Assisted now includes IVF intracytoplasmic sperm injection (ICSI). Therefore, it has become essential a routine to follow up for the outcome of ART cycles. This is done mainly by studying live birth rates, which main parameter success an cycle. It also mandatory neonatal outcomes addition rates. Studies on singleton pregnancies following cycles shown increased incidence perinatal complications, including preterm birth, very low weight, congenital anomalies. In most recent meta-analysis published Qin et al. 2017 (1Qin J.B. Sheng X.Q. Wu D. Gao S.Y. You Y.P. Yang T.B. al.Worldwide prevalence adverse pregnancy among after fertilization/intracytoplasmic injection: systematic review meta-analysis.Arch Gynecol Obstet. 2017; 295: 285-301Crossref PubMed Scopus (54) Google Scholar), pooled estimates were 10.9% (95% confidence interval [CI] 10.0–11.8) 2.4% CI 1.9–3.0) 8.7% 7.4–10.2) 2.0% 1.5–2.6) 7.1% 5.5–9.2) small gestational age, 1.1% 0.9–1.3) mortality, 5.7% 4.7–6.9) malformations. evident that patients with or ICSI higher risk than those naturally conceived Scholar). Similar reported older studies. 2004, Jackson (2Jackson R.A. Gibson K.A. Y.W. Croughan M.S. Perinatal singletons fertilization: meta-analysis.Obstet Gynecol. 2004; 103: 551-563Crossref (882) Scholar) comprising >12,000 compared 1.9 spontaneously pregnancies. results showed significantly odds other complications pregnancy, such as diabetes, preeclampsia, intensive care unit admissions. recommendation manage all high-risk ones. Since best monitored stillbirth important, separate entity should be reported. definition strictly defined. applied Sarmon (3Sarmon K.G. Eliasen T. Knudsen A.B. Bay B. technologies pregnancies: meta-analysis.Fert Stert. 2021; 116: 784-792Abstract Full Text PDF (3) Stillbirth defined fetal death occurring from 20 weeks till delivery; this important because combines various definitions Centers Disease Control Prevention, American College Obstetricians Gynecologists, Royal Gynaecologists. differentiate rates treatment modalities, ovulation induction artificial insemination, these techniques are expected more favorable (4Helmerhorst F.M. Perquin D.A. Donker Keirse M.J. twins conception: controlled studies.BMJ. 328: 261Crossref study include exclusively. point strength Another only included studies reporting (IVF ICSI). so not confound can 1 week birth. desirable cause at time definitely different before excluded multiple pregnancies, limiting pregnancies; analysis known outcomes. large number spontaneous total 1,860,055 births 6,952 stillbirths. occurs but subfertile women. children couples treated simpler fertility treatments, intrauterine controls, risks women lower confirms both subfertility influence born. When mother gave child compared, similar differences found, supporting theory slightly worse (5Bernsten S. Soderstrom-Anttila V. Wennerholm U.B. Laivuori H. Loft A. Oldereid N.B. al.The health ART: 'the chicken egg?'.Hum Reprod Update. 2019; 25: 137-158Crossref (113) suggests due intrinsic factors exist infertile couples, just undergoing procedure. tried subdivide data available into fresh frozen embryo transfers. clear presented whether affected rate. Definite conclusions about versus transfer produced meta-analysis. Larger prospective address issue needed, recommended article. conclusion, regards stillbirth. sufficient better management proper counseling embarking meta-analysisFertility SterilityVol. 116Issue 3PreviewTo identify types conception (SC), limited births. Full-Text